Human ANGPTL2/Angiopoietin-like 2 Protein 5177

$225.00 – $750.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Thr260-His493

available size

Clear

SKU: 5177parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9UKU9
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
molecular weight	The protein has a predicted MW of 30.1 kDa. Due to glycosylation, the protein migrates to 31-35 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human ANGPTL2/Angiopoietin-like 2 Protein 5177

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
Protein names
Angiopoietin-related protein 2 (Angiopoietin-like protein 2)
Gene names
ANGPTL2,ANGPTL2 ARP2 UNQ170/PRO196
Mass
9606Da
Function
Induces sprouting in endothelial cells through an autocrine and paracrine action.
Catalytic activity
#N/A
Subellular location
Secreted.
Tissues
Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.
Post-translational modification
N-glycosylated.
Target Relevance information above includes information from UniProt accession: Q9UKU9
The UniProt Consortium

Data

SPR with Human ANGPTL2/Angiopoietin-like 2 Protein

Human LILRB2, hFc Tag captured on CM5 Chip via Protein A can bind Human ANGPTL2, His Tag with an affinity constant of 0.22 µM as determined in SPR assay (Biacore T200).

HPLC of Human ANGPTL2/Angiopoietin-like 2 Protein

The purity of Human ANGPTL2 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human ANGPTL2/Angiopoietin-like 2 Protein

Human ANGPTL2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.