Human AGR-2 Protein 3281

$330.00 – $1,100.00

Summary

Expression: E.coli
Binding assay: Yes (SPR)
Amino Acid Range: Arg21-Leu175

SKU: 3281parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	NP_006399
express system	E.coli
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in a diverse range of biological systems, including vertebrate tissue development, inflammatory tissue injury responses, and cancer progression.
molecular weight	The protein has a predicted MW of 18.77 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human AGR-2 Protein 3281

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in a diverse range of biological systems, including vertebrate tissue development, inflammatory tissue injury responses, and cancer progression.
Protein names Anterior gradient protein 2 homolog (AG-2) (hAG-2) (HPC8) (Secreted cement gland protein XAG-2 homolog)
Protein family AGR family
Mass 19979Da
Function Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed:23274113). {ECO:0000250, ECO:0000269\|PubMed:18199544, ECO:0000269\|PubMed:23274113}.
Subellular location Secreted {ECO:0000269\|PubMed:15834940}. Endoplasmic reticulum {ECO:0000250\|UniProtKB:O88312}.
Tissues Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. {ECO:0000269\|PubMed:9790916}.
Structure Monomer and homodimer (PubMed:23274113). Interacts with LYPD3 and DAG1 (alphaDAG1) (PubMed:12592373). Interacts with MUC2; disulfide-linked (PubMed:19359471, PubMed:34237462). {ECO:0000269\|PubMed:12592373, ECO:0000269\|PubMed:19359471, ECO:0000269\|PubMed:23274113, ECO:0000269\|PubMed:34237462}.
Target Relevance information above includes information from UniProt accession: O95994
The UniProt Consortium

Data

Human EpCAM, hFc Tag captured on CM5 Chip via Protein A can bind Human AGR-2, His Tag with an affinity constant of 6.91 µM as determined in SPR assay (Biacore T200).

The purity of Human AGR-2 is greater than 95% as determined by SEC-HPLC.

Human AGR-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.