Human Adenylosuccinate Lyase Protein 2466

$300.00 – $1,000.00

Summary

Expression: E.coli
Pure: Yes (SDS-PAGE)
Amino Acid Range: Ala2-Leu484

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SKU: 2466parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P30566
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE
background	Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine biosynthesis, ADSL functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. Adenylosuccinate lyase ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nucleotide recycling pathways.
molecular weight	The protein has a predicted MW of 56.28 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Adenylosuccinate Lyase Protein 2466

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine biosynthesis, ADSL functions in de novo purine synthesis (DNPS) and the purine nucleotide cycle. Adenylosuccinate lyase ADSL) deficiency is a defect of purine metabolism affecting purinosome assembly and reducing metabolite fluxes through purine de novo synthesis and purine nucleotide recycling pathways.
Protein names Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)
Gene names ADSL,ADSL AMPS
Protein family Lyase 1 family, Adenylosuccinate lyase subfamily
Mass 9606Da
Function Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Catalytic activity #N/A
Pathway PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole
Tissues Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1.
Structure Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.
Target Relevance information above includes information from UniProt accession: P30566
The UniProt Consortium

Data

SDS-PAGE gel of Human Adenylosuccinate Lyase~-Protein

Human Adenylosuccinate Lyase on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.