| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| accession | P78325 |
| express system | HEK293 |
| product tag | C-His |
| purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| background | A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. |
| molecular weight | The protein has a predicted MW of 70.9 kDa. The protein migrates to 55-70 kDa based on Tris-Bis PAGE result. |
| available size | 100 µg, 500 µg |
| endotoxin | Less than 1EU per μg by the LAL method. |
Human ADAM8 Protein 3567
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Active: Yes (catalytic)
- Amino Acid Range: Ile17-Pro655
Human ADAM8 Protein 3567
| protein |
|---|
| Size and concentration 100, 500µg and lyophilized |
| Form Lyophilized |
| Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Storage buffer Shipped at ambient temperature. |
| Purity > 95% as determined by Tris-Bis PAGE |
| target relevance |
|---|
| A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. |
| Protein names Disintegrin and metalloproteinase domain-containing protein 8 (ADAM 8) (EC 3.4.24.-) (Cell surface antigen MS2) (CD antigen CD156a) |
| Gene names ADAM8,ADAM8 MS2 |
| Mass 9606Da |
| Function Possible involvement in extravasation of leukocytes. |
| Catalytic activity BINDING 334; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_note="catalytic"; /evidence="ECO:0000269|PubMed:22684055"; BINDING 338; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_note="catalytic"; /evidence="ECO:0000269|PubMed:22684055"; BINDING 344; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_note="catalytic"; /evidence="ECO:0000269|PubMed:22684055" |
| Subellular location Membrane; Single-pass type I membrane protein. |
| Tissues Expressed on neutrophils and monocytes. |
| Structure Interacts with FST3. |
| Target Relevance information above includes information from UniProt accession: P78325 |
| The UniProt Consortium |
