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Human 4-1BB/TNFRSF9 Protein 4408

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu24-Gln186
SKU: 4408parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q07011

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

molecular weight

The protein has a predicted MW of 18.1 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human 4-1BB/TNFRSF9 Protein 4408

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
Protein names
Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)
Gene names
TNFRSF9,TNFRSF9 CD137 ILA
Mass
9606Da
Function
FUNCTION: Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable). {ECO:0000305|PubMed:30872117}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000305|PubMed:30872117}.
Tissues
TISSUE SPECIFICITY: Expressed on the surface of activated T-cells. {ECO:0000269|PubMed:30872117}.
Structure
SUBUNIT: Predominantly homodimeric, but may also exist as a monomer (By similarity). Interacts with TRAF1, TRAF2 and TRAF3 (PubMed:9418902, PubMed:9607925). Interacts with LRR-repeat protein 1/LRR-1 (PubMed:11804328). {ECO:0000250|UniProtKB:P20334, ECO:0000269|PubMed:11804328, ECO:0000269|PubMed:9418902, ECO:0000269|PubMed:9607925}.
Target Relevance information above includes information from UniProt accession : Q07011
The UniProt Consortium

Data

ELISA with Human 4-1BB/TNFRSF9 Protein
Immobilized Human 4-1BB, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human 4-1BB Ligand Trimer, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA.
HPLC of Human 4-1BB/TNFRSF9 Protein
The purity of Human 4-1BB is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human 4-1BB/TNFRSF9 Protein
Human 4-1BB on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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