HRSV (A, strain Long) Glycoprotein G Protein 2856

$225.00 – $750.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: His67-Gln298

available size

Clear

SKU: 2856parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P20895
express system	HEK293
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Glycoprotein G (gG) here refers to the adhesion protein on the surface of RSV, It is a type II glycoprotein and one of the two main envelope glycoproteins of RSV. Glycoprotein G can bind to the host cell membrane receptor and mediate the entry of the virus into the host cell.
molecular weight	The protein has a predicted MW of 26.29 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

HRSV (A, strain Long) Glycoprotein G Protein 2856

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Glycoprotein G (gG) here refers to the adhesion protein on the surface of RSV, It is a type II glycoprotein and one of the two main envelope glycoproteins of RSV. Glycoprotein G can bind to the host cell membrane receptor and mediate the entry of the virus into the host cell.
Protein names Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG) [Cleaved into: Mature secreted glycoprotein G (Mature sG)]
Gene names G,G
Protein family Pneumoviruses glycoprotein G family
Mass 11250Da
Function [Isoform Membrane-bound glycoprotein G]: Attaches the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Interacts with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, lacks both neuraminidase and hemagglutinating activities.; [Isoform Secreted glycoprotein G]: Helps the virus escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fc-gamma receptors.
Catalytic activity #N/A
Subellular location [Isoform Membrane-bound glycoprotein G]: Virion membrane ; Single-pass type II membrane protein. Host cell membrane ; Single-pass type II membrane protein .; [Isoform Secreted glycoprotein G]: Secreted. Note=The protein is shed from infected cells before the appearance of progeny virus (PubMed:3373568). The initiation at the downstream methionine removes a portion of the transmembrane domain. The remaining hydrophobic portion of the sG protein is essential for translocating it into the lumen of the ER during translation and would likely maintain its membrane association until a proteolytic event releases the mature sG protein into the medium (Probable).
Structure [Isoform Membrane-bound glycoprotein G]: Homooligomer. Interacts (via N-terminus) with protein M. Part of a complex composed of F1, F2 and G glycoproteins. Interacts with protein SH. Interacts with host heparate sulfate; this interaction probably participates in the viral attachment to the host cell. Interacts with host CX3CR1; this interaction plays an important role in viral entry. Interacts with the host lectins CD209/DC-SIGN and CD209L/L-SIGN on dendritic cells; these interactions stimulate the phosphorylation of MAPK3/ERK1 and MAPK1/ERK2, which inhibits dendritic cell activation and could participate in the limited immunity against RSV reinfection.
Post-translational modification [Isoform Secreted glycoprotein G]: Cleaved to give rise to the mature sG protein which lacks the transmembrane domain.
Domain [I
Target Relevance information above includes information from UniProt accession: P20895
The UniProt Consortium

Data

HPLC of HRSV (A, strain Long) Glycoprotein G Protein

The purity of HRSV (A, strain Long) Glycoprotein G is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of HRSV (A, strain Long) Glycoprotein G Protein

HRSV (A, strain Long) Glycoprotein G on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.