Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick kit 5372

Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick kit 5372 - Image 2

Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick kit 5372

$478.00

Summary

Mikrogen diagnostik lateral flow device (dipstick) for research use (RUO)
Herpes Simplex Virus (HSV) 1 and 2 IgG ELISA Kit
Suitable for IgG detection
Ready-to-use
20 tests

SKU: 5372 Category: Mikrogen kits Tags: Herpes simplex Virus, IgG, Lateral Flow Dipsticks

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Herpes simplex Virus 1 and 2 reactive IgG
species reactivity	Herpes Simplex Virus
applications	Lateral flow (dipstick)
assay type	Indirect & qualitative
available sizes	2x 20 test kits

Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick 5372

Assay type
Sandwich assay, lateral flow (dipstick)

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instructions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 kits of [2 Vials x 10 Each]
Anti-Human IgG Conjugate	500 µL
Positive Control	140 µL
Negative Control	140 µL

Storage
Store at 2-8°C.

Additional information
Mikrogen recomLine HSV-1 & HSV-2 IgG Test

Mikrogen recomLine HSV-1 & HSV-2 IgG Test is a serological, qualitative in vitro line immunoassay based on purified, subtype-specific recombinant gG1 (HSV-1) and gG2 (HSV-2) antigens, ensuring accurate differentiation of HSV-1 and HSV-2 infections.

Most serologic methods for determining HSV status use viral lysate as antigens and cannot distinguish between HSV-1 and HSV-2 infections due to cross-reactivity. Since most adults have already had an HSV-1 infection (seroprevalence is approximately 83% in Germany), serological status for HSV-2 cannot be reliably diagnosed using viral lysates.

Advantages

Highest sensitivity and specificity due to the use of recombinant antigens: gG1 (HSV-1) and gG2 (HSV-2).
Application as serological confirmation or supplement for PCR and/or cell culture findings, after positive screening with HSV ELISA.
Application for determination of subtype-specific HSV serostatus of risk groups:
- Herpes genitalis positive patients and their partners.
- Patients with an increased risk for sexually transmitted diseases.
- Immunosuppressed patients (e.g., HIV seropositive, transplant patients).
- Recurrent genital and anal infections.
- Pregnancy (risk assessment of primary HSV infection or risk of herpes neonatorum).
No cross-reactions.
Easy and clear interpretation due to easy-to-read banding.
Partial and full automation, software-based evaluation (recomScan), and integration with laboratory information system possible.

target relevance

human antibody anti-Herpes Simplex Virus (HSV)

Herpes Simplex Virus (HSV)

Description
Virus that causes oral herpes, genital herpes, and other mucocutaneous infections

Structure
Herpes simplex viruses (HSV) are enveloped, double-stranded DNA viruses belonging to the genus Simplexvirus within the family Herpesviridae. Two closely related species, Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), are responsible for the majority of human infections. The viral genome is enclosed within an icosahedral capsid surrounded by a protein tegument and a lipid envelope containing glycoproteins that mediate attachment and entry into host cells. Following primary infection, HSV establishes lifelong latency within sensory neurons, particularly in the trigeminal and sacral ganglia. Periodic reactivation of latent virus results in recurrent infections and viral shedding, often in the absence of symptoms. HSV infections are widespread globally and represent some of the most common viral infections of humans.

Diagnosis
The diagnosis of herpes simplex virus infection is performed through clinical evaluation and laboratory testing. Molecular methods such as polymerase chain reaction (PCR) are highly sensitive and specific and are considered the preferred diagnostic approach for detecting HSV DNA in lesion swabs, cerebrospinal fluid, and other clinical specimens. Viral culture may also be used, particularly for active lesions, although it is generally less sensitive than PCR. Direct fluorescent antibody testing and antigen detection assays may provide rapid identification in selected settings. Serological assays, including ELISA-based tests, can detect HSV-specific antibodies and help distinguish previous exposure to HSV-1 and HSV-2. Laboratory confirmation is particularly important in cases of neonatal herpes, encephalitis, and atypical presentations.

Symptoms
Herpes simplex virus infections produce a wide range of clinical manifestations depending on the site of infection and immune status of the host. Primary infection may be asymptomatic or may present with painful vesicular lesions involving the oral cavity, lips, genital region, skin, or eyes. HSV-1 most commonly causes oral herpes characterized by fever, gingivostomatitis, and recurrent cold sores, whereas HSV-2 is more frequently associated with genital herpes causing painful ulcers, itching, dysuria, and regional lymphadenopathy. Recurrent episodes are typically milder than primary infections due to partial immune control. In immunocompromised individuals and neonates, HSV can cause severe disseminated disease. Rare but serious complications include herpes encephalitis, keratitis leading to vision loss, meningitis, and neonatal herpes, which may be life-threatening if untreated.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick kit 5372?

The kit is compatible with serum, plasma, and whole blood samples for the detection of Herpes simplex Virus 1 and 2 reactive IgG antibodies using a lateral flow dipstick assay.

How should the Herpes simplex Virus 1 and 2 IgG Lateral flow dipstick kit 5372 be stored to maintain its stability?

The kit components should be stored at 2-8°C to ensure optimal stability and performance during research use.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU). 5372 protocol