| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | goat |
| isotype | IgG |
| clonality | polyclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Human IgE |
| available sizes | 1 mg |
goat anti-Human IgE polyclonal antibody 7405
$293.00
Antibody summary
- Goat polyclonal to Human IgE
- Suitable for: WB,IHC,ICC,ELISA
- Isotype: Whole IgG
- 1 mg
goat anti-Human IgE polyclonal antibody 7405
| antibody |
|---|
| Tested applications WB,IHC,IHC,ICC/IF,ELISA |
| Recommended dilutions ELISA Coating: 1:100-1:500, Primary: 1:1,000-1:30,000 Western Blot - Colorimetric 1:1,000-1:10,000, Chemiluminescent: 1:1,000-1:30,000 Immunohistochemistry: 1:200-1:2,000 Immuocytochemistry: 1:200-1:2,000 These are recommended dilutions only. End user should d |
| Immunogen Purified human IgE |
| Size and concentration 1mg and 1 mg/mL |
| Form liquid |
| Storage Instructions Store at 2-8°C. Expires 2 years from date of receipt. |
| Storage buffer Phosphate Buffered Saline (PBS) containing 0.09 |
| Purity peptide affinity purification |
| Clonality polyclonal |
| Isotype IgG |
| Compatible secondaries donkey anti-goat IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 1689 donkey anti-goat IgG, H&L chain specific, biotin conjugated polyclonal antibody 1699 donkey anti-goat IgG, H&L chain specific, FITC conjugated polyclonal antibody 1704 donkey anti-goat IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1709 donkey anti-goat IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1705 |
| Isotype control Goat polyclonal - Isotype Control |
| target relevance |
|---|
| human IgE |
| Protein names Immunoglobulin E |
| Alternative names IgE, E immunoglobulin, Epsilon immunoglobulin |
| Function IgE mediates immediate hypersensitivity reactions by binding allergens and cross-linking Fc epsilon receptors on mast cells and basophils, triggering release of histamine, leukotrienes, cytokines, and other inflammatory mediators. |
| Subcellular location Secreted; found in blood plasma, extracellular fluids, and bound to Fc epsilon receptors on mast cells, basophils, eosinophils, dendritic cells, and other immune cells. |
| Structure IgE is composed of two epsilon heavy chains and two light chains linked by disulfide bonds. Unlike IgG, the epsilon heavy chain contains four constant domains and lacks a classical hinge region. |
| Description Immunoglobulin E (IgE) is an antibody isotype involved in allergic responses, hypersensitivity reactions, and immunity against parasitic infections. IgE binds with high affinity to Fc epsilon receptors on mast cells and basophils and plays a central role in type I hypersensitivity reactions. |
| Related entities relationship: binds_to; entity: FCER1A relationship: binds_to; entity: CD23 relationship: related_to; entity: Immunoglobulin G relationship: related_to; entity: Immunoglobulin A relationship: related_to; entity: Immunoglobulin M |
| Keywords Antibody, Immunoglobulin, Allergy, Hypersensitivity, Anti-parasitic immunity |
| Structure IgE is a tetrameric antibody composed of two epsilon heavy chains and two light chains. The epsilon heavy chain contains four constant domains and lacks a classical hinge region. |
| Function IgE mediates allergic and antiparasitic immune responses through high-affinity binding to Fc epsilon receptors on mast cells and basophils. |
| Receptor binding IgE binds Fc epsilon receptor I (FcεRI) with exceptionally high affinity and can also interact with Fc epsilon receptor II (CD23). |
| Clinical relevance Elevated IgE levels are associated with allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food allergy, and anaphylaxis. Total and allergen-specific IgE measurements are widely used in allergy diagnostics. |
| Research relevance IgE is extensively studied in allergy, immunology, mast cell biology, parasitology, asthma research, and therapeutic antibody development. |
Data
| No results found |
FAQ & Publications
Frequently Asked Questions
What applications has the goat anti-Human IgE polyclonal antibody 7405 been tested for?
The goat anti-Human IgE polyclonal antibody 7405 has been tested and is suitable for Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry/Immunofluorescence (ICC/IF), and ELISA applications.
How should the goat anti-Human IgE polyclonal antibody 7405 be stored to maintain its stability?
This antibody should be stored at 2-8°C and is stable for up to 2 years from the date of receipt under these conditions.
What is the immunogen used to generate the goat anti-Human IgE polyclonal antibody 7405, and what is its species reactivity?
The immunogen for this antibody is purified human IgE, and the antibody specifically reacts with human IgE.
Publications
| pmid | title | authors | citation |
|---|---|---|---|
| We haven't added any publications to our database yet. | |||
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
Protocols
| relevant to this product |
|---|
| Western blot IHC ICC |
Documents
| Batch Number | QC File | SDS |
|---|---|---|
| To view batch-specific Safety Datasheets and Quality Certificates associated with your account, please Log In. | ||
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