Cynomolgus Oncostatin M/OSM Protein 2241

$315.00 – $1,050.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Ala27-Arg221

available size

Clear

SKU: 2241parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_045219762
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
molecular weight	The protein has a predicted MW of 23.31 kDa. Due to glycosylation, the protein migrates to 27-50 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus Oncostatin M/OSM Protein 2241

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
OSM is a pleiotropic cytokine that initiates its biological activities by binding to specific cell surface receptors. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Protein names Oncostatin M
Gene names OSM,OSM
Mass 9615Da
Subellular location Secreted .
Target Relevance information above includes information from UniProt accession: A0A8I3Q5M1
The UniProt Consortium

Data

SPR with Cynomolgus Oncostatin M/OSM Protein

Human LIF R, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus OSM, His Tag with an affinity constant of 1.31 µM as determined in SPR assay (Biacore T200).

HPLC of Cynomolgus Oncostatin M/OSM Protein

The purity of Cynomolgus Oncostatin M is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus Oncostatin M/OSM Protein

Cynomolgus Oncostatin M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.