Cynomolgus GPVI Protein 2783

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Gln21-Asn251

SKU: 2783parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_005590417.2
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
molecular weight	The protein has a predicted MW of 26.42 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus GPVI Protein 2783

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair. Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM). GPVI is activated by collagen in the subendothelial matrix, by fibrin and fibrinogen in the thrombus, and by a remarkable number of other ligands.
Protein names Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Mass 36866Da
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. {ECO:0000269\|PubMed:10961879, ECO:0000269\|PubMed:18955485}.
Subellular location [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Cell membrane; Single-pass membrane protein.
Tissues Megakaryocytes and platelets. {ECO:0000269\|PubMed:10961879}.
Structure Associated with Fc receptor gamma chain. The GPVI:FcRgamma complex is associated with the Src kinase family FYN and LYN (PubMed:10961879, PubMed:9295288). Interacts with TRAF4 (PubMed:20946164). Interacts with COL1A1, but not with COL4A4 (By similarity). {ECO:0000250\|UniProtKB:P0C191, ECO:0000269\|PubMed:10961879, ECO:0000269\|PubMed:9295288}.; (Microbial infection) Interacts with Staphylococcus aureus protein SSL5. {ECO:0000269\|PubMed:21552524}.
Post-translational modification N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX). {ECO:0000269\|PubMed:16014566}.
Target Relevance information above includes information from UniProt accession: Q9HCN6
The UniProt Consortium

Data

Immobilized Cynomolgus GPVI, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 5.3ng/ml determined by ELISA.

The purity of Cynomolgus GPVI is greater than 95% as determined by SEC-HPLC.

Cynomolgus GPVI on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.