Skip to content

Cynomolgus AMIGO2 Protein 3112

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Val39-Thr397
SKU: 3112parent Categories: , Tag:
Weight 1 lbs
Dimensions 9 × 5 × 2 in
accession

G7PHN7

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.

molecular weight

The protein has a predicted MW of 41.97 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus AMIGO2 Protein 3112

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.
Protein names
Adhesion molecule with Ig like domain 2
Gene names
AMIGO2,AMIGO2
Protein family
Immunoglobulin superfamily, AMIGO family
Mass
9541Da
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: G7PHN7
The UniProt Consortium

Data

HPLC of Cynomolgus AMIGO2 Protein
The purity of Cynomolgus AMIGO2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus AMIGO2 Protein
Cynomolgus AMIGO2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Publications

pmid title authors citation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product

Documents

#
Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information.