Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | G7PHN7 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis. |
molecular weight | The protein has a predicted MW of 41.97 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Cynomolgus AMIGO2 Protein 3112
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Val39-Thr397
Cynomolgus AMIGO2 Protein 3112
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis. |
Protein names Adhesion molecule with Ig like domain 2 |
Gene names AMIGO2,AMIGO2 |
Protein family Immunoglobulin superfamily, AMIGO family |
Mass 9541Da |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Target Relevance information above includes information from UniProt accession: G7PHN7 |
The UniProt Consortium |
Data
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The purity of Cynomolgus AMIGO2 is greater than 95% as determined by SEC-HPLC. |
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Cynomolgus AMIGO2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
Publications
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We haven't added any publications to our database yet. |
Protocols
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