Cynomolgus ALCAM/CD166 Protein 2797

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Trp28-Lys527

SKU: 2797parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	G7NZQ8
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM.
molecular weight	The protein has a predicted MW of 57.10 kDa. Due to glycosylation, the protein migrates to 70-85 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus ALCAM/CD166 Protein 2797

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM.
Protein names CD166 antigen (Activated leukocyte cell adhesion molecule)
Gene names ALCAM,ALCAM EGM_10314
Mass 9541Da
Subellular location Cell membrane ; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: G7NZQ8
The UniProt Consortium

Data

ELISA with Cynomolgus ALCAM/CD166 Protein

Immobilized Cynomolgus ALCAM, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-ALCAM Antibody, hFc Tag with the EC50 of 0.22µg/ml determined by ELISA.

The purity of Cynomolgus ALCAM is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus ALCAM/CD166 Protein

Cynomolgus ALCAM on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.