SPR with Biotinylated Mouse IL-22 Protein 3353

ELISA with Biotinylated Mouse IL-22 Protein 3353

Biotinylated Mouse IL-22 Protein 3353

$525.00 – $1,750.00

Summary

Expression: E.coli
Functional: Yes (ELISA)
Amino Acid Range: Leu34-Val179

SKU: 3353parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
express system	E.coli
product tag	N-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.
molecular weight	The protein has a predicted MW of 19.7 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Biotinylated Mouse IL-22 Protein 3353

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.
Protein names Interleukin-22 (IL-22) (IL-10-related T-cell-derived-inducible factor) (IL-TIF) (IL-TIF alpha) (Interleukin-22a) (IL-22a)
Gene names Il22,Il22 Il22a Iltif Iltifa
Protein family IL-10 family
Mass 20106Da
Function FUNCTION: Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:33852830, PubMed:35525330). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:33912578). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (PubMed:24742671). Promotes epithelial cell spreading (PubMed:24742671). {ECO:0000250\|UniProtKB:Q9GZX6, ECO:0000269\|PubMed:24742671, ECO:0000269\|PubMed:33852830, ECO:0000269\|PubMed:33912578, ECO:0000269\|PubMed:35525330}.
Subellular location SUBCELLULAR LOCATION: Secreted.
Target Relevance information above includes information from UniProt accession: Q9JJY9
The UniProt Consortium

Data

No results found

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.