Biotinylated Mouse GUCY2C/Guanylyl cyclase C Protein 2676

$525.00 – $1,750.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Val20-Met433

available size

Clear

SKU: 2676parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
molecular weight	The protein has a predicted MW of 50.01 kDa. Due to glycosylation, the protein migrates to 70-100 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Biotinylated Mouse GUCY2C/Guanylyl cyclase C Protein 2676

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy.
Protein names Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (Intestinal guanylate cyclase)
Gene names Gucy2c,Gucy2c Guc2c
Protein family Adenylyl cyclase class-4/guanylyl cyclase family
Mass 10090Da
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP.
Catalytic activity #N/A
Subellular location Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
Structure Homotrimer. Interacts via its C-terminal region with NHERF4. Interacts with the lectin chaperone VIP36.
Post-translational modification Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation.
Domain Th
Target Relevance information above includes information from UniProt accession: Q3UWA6
The UniProt Consortium

Data

HPLC of Biotinylated Mouse GUCY2C/Guanylyl cyclase C Protein

The purity of Biotinylated Mouse GUCY2C is greater than 90% as determined by SEC-HPLC.

SDS-PAGE gel of Biotinylated Mouse GUCY2C/Guanylyl cyclase C Protein

Biotinylated Mouse GUCY2C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.