HPLC of Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary Amine Lab 2728

SDS-PAGE gel of Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary A 2728

Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary Amine Labeling) 2728

$525.00 – $1,750.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Phe26-Met786

SKU: 2728parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
molecular weight	The protein has a predicted MW of 85.4 kDa. Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary Amine Labeling) 2728

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Protein names Cadherin-17 (BILL-cadherin) (Liver-intestine cadherin) (LI-cadherin) (P130)
Gene names Cdh17,Cdh17
Mass 10090Da
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.
Subellular location Cell membrane ; Single-pass type I membrane protein .
Tissues Highest expression is found in intestine with lower expression in spleen, bone marrow, lung and testis. No expression detected in liver, kidney, heart, brain or skeletal muscle. Expressed in precursor B-cells and myeloid cells.
Domain Th
Target Relevance information above includes information from UniProt accession: Q9R100
The UniProt Consortium

HPLC of Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary Amine Lab

The purity of Biotinylated Mouse CDH17 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Biotinylated Mouse CDH17/Cadherin 17 Protein (Primary A

Biotinylated Mouse CDH17 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.