Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
express system | CHO |
product tag | C-His-Avi |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. |
molecular weight | The protein has a predicted MW of 60.7 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Biotinylated Human LRRC15/LIB Protein 4296
$525.00 – $1,750.00
Summary
- Expression: CHO
- Functional: Yes (ELISA)
- Amino Acid Range: Tyr22-Gly538
Biotinylated Human LRRC15/LIB Protein 4296
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge of migrating cells, the expression of which in normal tissues is restricted to the invasive cytotrophoblast layer of the placenta; small interfering (siRNA)-mediated suppression of LRRC15 expression in breast cancer cells leads to abrogation of invasiveness in vitro. |
Protein names Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib) |
Gene names LRRC15,LRRC15 LIB |
Mass 9606Da |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Expressed in brain and placenta (PubMed:11785964). Expressed in lung fibroblasts (PubMed:36228039, PubMed:36757924). Expressed in chodrocytes (PubMed:34702854). |
Target Relevance information above includes information from UniProt accession: Q8TF66 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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