Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P56747 |
express system | HEK293 |
product tag | |
purity | > 95% as determined by HPLC |
background | Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. |
molecular weight | The target protein has a predicted MW of 24.5 kDa. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μl by the LAL method. |
Biotinylated Human Claudin 6 Protein-VLP 4250
$1,969.00
Summary
- Expression: HEK293
- Binding assay: Yes (SPR)
- Amino Acid Range: Met1-Val220
Biotinylated Human Claudin 6 Protein-VLP 4250
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Claudin-6 is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Human Claudin-6 shares 88% and 86% amino acid sequence identity with mouse and rat Claudin-6, respectively. |
Protein names Claudin-6 (Skullin) |
Gene names CLDN6,CLDN6 UNQ757/PRO1488 |
Protein family Claudin family |
Mass 9606Da |
Function Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. |
Subellular location Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein . |
Tissues Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines. |
Structure Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). Interacts with CLDN1, CD81 and OCLN (PubMed:20375010). |
Target Relevance information above includes information from UniProt accession: P56747 |
The UniProt Consortium |
Publications
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