Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) 2670

$525.00 – $1,750.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Thr28-Pro207

available size

Clear

SKU: 2670parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
molecular weight	The protein has a predicted MW of 21.14 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling) 2670

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Protein names Interleukin-18-binding protein
Mass 9541Da
Target Relevance information above includes information from UniProt accession: A0A2K5UDJ4
The UniProt Consortium

Data

SPR with Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labelin

Biotinylated Cynomolgus IL-18BP, His tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 1.67 nM as determined in SPR assay (Biacore T200).

HPLC of Biotinylated Cynomolgus IL-18BP Protein (Primary Amine Labeling

The purity of Biotinylated Cynomolgus IL-18BP is greater than 90% as determined by SEC-HPLC.

SDS-PAGE gel of Biotinylated Cynomolgus IL-18BP Protein (Primary Amine

Biotinylated Cynomolgus IL-18BP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.