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INI-1

INI-1: INI-1 is a tumor suppressor protein frequently lost in malignant rhabdoid tumors and other aggressive neoplasms. Its detection is critical for diagnosis, as loss of INI-1 expression through IHC aids in distinguishing these tumors from other small round blue cell tumors.



Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of tumor cells, whereas the background cells are positive.
IHC with antibody [6230] : Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of tumor cells, whereas the background cells are positive.
Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of stromal/endothelial cells and absence of staining in tumor cells, whereas the background cells with nuclear staining.
IHC with antibody [6231] : Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of stromal/endothelial cells and absence of staining in tumor cells, whereas the background cells with nuclear staining.
ICC