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CCL4 (MIP-1B)
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
| target | type | reactivity | applications | ||||
|---|---|---|---|---|---|---|---|
| 8018 | Biotininylated CCL4 (MIP-1B) | human | |||||
| 6005 | CCL4 (MIP-1B) | human | |||||
Migration assay with [8018] : Cells expressing recombinant CCR5 were assayed for migration through a transwell filter at various concentrations of WT or Biotinylated MIP-1β. Responses are expressed as the % of total input cells (Blue: wild type; Red: biotinylated).
