Mouse DDC Protein 2261

$300.00 – $1,000.00

Summary

Expression: Baculovirus-Insect Cells
Active: Yes (catalytic)
Amino Acid Range: Met1-Glu480

SKU: 2261parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O88533
express system	Baculovirus-Insect Cells
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic symptoms including oculogyric crises (OGC), sleep disorder, and mood disturbance.
molecular weight	The protein has a predicted MW of 55.40 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse DDC Protein 2261

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral, and autonomic symptoms including oculogyric crises (OGC), sleep disorder, and mood disturbance.
Protein names Aromatic-L-amino-acid decarboxylase (AADC) (EC 4.1.1.28) (DOPA decarboxylase) (DDC)
Gene names Ddc,Ddc
Protein family Group II decarboxylase family
Mass 10090Da
Function Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.
Catalytic activity BINDING 82; /ligand="substrate"; /evidence="ECO:0000250\|UniProtKB:P80041"; BINDING 148; /ligand="pyridoxal 5'-phosphate"; /ligand_id="ChEBI:CHEBI:597326"; /evidence="ECO:0000250\|UniProtKB:P20711"; BINDING 149; /ligand="pyridoxal 5'-phosphate"; /ligand_id="ChEBI:CHEBI:597326"; /evidence="ECO:0000250\|UniProtKB:P20711"; BINDING 192; /ligand="substrate"; /evidence="ECO:0000250\|UniProtKB:P80041"; BINDING 246; /ligand="pyridoxal 5'-phosphate"; /ligand_id="ChEBI:CHEBI:597326"; /evidence="ECO:0000250\|UniProtKB:P20711"; BINDING 300; /ligand="pyridoxal 5'-phosphate"; /ligand_id="ChEBI:CHEBI:597326"; /evidence="ECO:0000250\|UniProtKB:P20711"
Pathway PATHWAY: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
Structure Homodimer.
Target Relevance information above includes information from UniProt accession: O88533
The UniProt Consortium

Data

Measured by its ability to convert the substrate 3, 4-dihydroxy L-phenylalanine (L-Dopa) to 3, 4-dihydroxyphenylethylamine (dopamine). The dopamine product is measured by its absorbance at 340 nm after derivatization with trinitrobenzene sulfonic acid. The specific activity is >1500 pmol/min/µg, as measured under the described°Conditions.

The purity of Mouse DDC is greater than 95% as determined by SEC-HPLC.

Mouse DDC on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.