ELISA with Human NKp46/NCR1/CD335 Protein 4861

Human NKp46/NCR1/CD335 Protein 4861

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Gln22-Asn255

SKU: 4861parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O76036
express system	HEK293
product tag	C-mFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
molecular weight	The protein has a predicted MW of 52.9 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human NKp46/NCR1/CD335 Protein 4861

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
Protein names Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335)
Gene names NCR1,NCR1 LY94
Protein family Natural cytotoxicity receptor (NCR) family
Mass 9606Da
Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subellular location Cell membrane ; Single-pass type I membrane protein .
Tissues Selectively expressed by both resting and activated NK cells.
Structure Interacts with CD247 and FCER1G.
Post-translational modification N-glycosylated.; O-glycosylated.
Target Relevance information above includes information from UniProt accession: O76036
The UniProt Consortium

Data

ELISA with Human NKp46/NCR1/CD335 Protein

Immobilized Human NKp46, mFc Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-Nkp46 Antibody, hFc Tag with the EC50 of 30.9ng/ml determined by ELISA.

The purity of Human NKp46 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human NKp46/NCR1/CD335 Protein

Human NKp46 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.