ELISA with Human CD200/OX-2 Protein 4251

Human CD200/OX-2 Protein 4251

$195.00 – $650.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Gln31-Gly232

SKU: 4251parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P41217
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.
molecular weight	The protein has a predicted MW of 49.2 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CD200/OX-2 Protein 4251

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.
Protein names OX-2 membrane glycoprotein (CD antigen CD200)
Gene names CD200,CD200 MOX1 MOX2 My033
Mass 9606Da
Function Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Subellular location Cell membrane; Single-pass type I membrane protein.
Structure CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.
Target Relevance information above includes information from UniProt accession: P41217
The UniProt Consortium

Data

Immobilized Human CD200 R1, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human CD200, hFc Tag with the EC50 of 0.77ng/ml determined by ELISA.

The purity of Human CD200 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human CD200/OX-2 Protein

Human CD200 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.