Human SECTM1 Protein 3693

$195.00 – $650.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Gln29-Gly145

SKU: 3693parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	AAH17716
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	SECTM1 is a T/NK cell "co-stimulatory" molecule that is expressed in the peripheral blood by neutrophils and monocytes.Human monocytic cells also displayed a pronounced negative regulation of SECTM1 mRNA expression by LPS, while at the protein level SECTM1 expression was also shown to be regulated by IFN and LPS. This tight regulation of SECTM1 gene expression and rapid upregulation highlights its relevance in the innate immune response.
molecular weight	The protein has a predicted MW of 39.4 kDa. Due to glycosylation, the protein migrates to 47-50 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human SECTM1 Protein 3693

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
SECTM1 is a T/NK cell "co-stimulatory" molecule that is expressed in the peripheral blood by neutrophils and monocytes.Human monocytic cells also displayed a pronounced negative regulation of SECTM1 mRNA expression by LPS, while at the protein level SECTM1 expression was also shown to be regulated by IFN and LPS. This tight regulation of SECTM1 gene expression and rapid upregulation highlights its relevance in the innate immune response.
Protein names Secreted and transmembrane protein 1 (Protein K-12)
Protein family SECTM family
Mass 27039Da
Function May be involved in thymocyte signaling. {ECO:0000269\|PubMed:15742156}.
Subellular location Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted.
Tissues Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts. {ECO:0000269\|PubMed:15742156, ECO:0000269\|PubMed:9480746}.
Structure Interacts with CD7. {ECO:0000269\|PubMed:10652336, ECO:0000269\|PubMed:15742156}.
Target Relevance information above includes information from UniProt accession: Q8WVN6
The UniProt Consortium

Data

Immobilized Human CD7, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human SECTM1, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.

The purity of Human SECTM1 is greater than 95% as determined by SEC-HPLC.

Human SECTM1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.