Mouse TRAIL/TNFRSF10 Protein 3614

$218.00 – $725.00

Summary

Expression: E.coli
Binding assay: Yes (SPR)
Amino Acid Range: Pro118-Asn291

SKU: 3614parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P50592
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE
background	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
molecular weight	The protein has a predicted MW of 30.6 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse TRAIL/TNFRSF10 Protein 3614
protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
Protein names
Tumor necrosis factor ligand superfamily member 10 (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
Gene names
Tnfsf10,Tnfsf10 Trail
Protein family
Tumor necrosis factor family
Mass
10090Da
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Catalytic activity
BINDING 240; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_note="ligand shared between all trimeric partners"; /evidence="ECO:0000250|UniProtKB:P50591"
Subellular location
Cell membrane ; Single-pass type II membrane protein. Secreted. Note=Exists both as membrane-bound and soluble form.
Tissues
Widespread.
Structure
Homotrimer. One TNFSF10 homotrimer interacts with three TNFSF10A mononers. One TNFSF10 homotrimer interacts with three TNFSF10B mononers.
Post-translational modification
Tyrosine phosphorylated by PKDCC/VLK.
Target Relevance information above includes information from UniProt accession: P50592
The UniProt Consortium

Human TRAIL R1, hFc Tag captured on CM5 Chip via Protein A can bind Mouse TRAIL, His Tag with an affinity constant of 0.62 µM as determined in SPR assay (Biacore T200).

SDS-PAGE gel of Mouse TRAIL/TNFRSF10 Protein

Mouse TRAIL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.