Human DSG-2/Desmoglein-2 Protein 3558

$270.00 – $900.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Ala50-Gly609

SKU: 3558parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q14126
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.
molecular weight	The protein has a predicted MW of 63.6 kDa. Due to glycosylation, the protein migrates to 75-80 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human DSG-2/Desmoglein-2 Protein 3558

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.
Protein names Desmoglein-2 (Cadherin family member 5) (HDGC)
Gene names DSG2,DSG2 CDHF5
Mass 9606Da
Function Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subellular location Cell membrane ; Single-pass type I membrane protein. Cell junction, desmosome .
Tissues All of the tissues tested and carcinomas.
Structure Interacts with PKP2.
Post-translational modification Palmitoylated by ZDHHC5 at the plasma membrane.
Domain Th
Target Relevance information above includes information from UniProt accession: Q14126
The UniProt Consortium

Data

ELISA with Human DSG-2/Desmoglein-2 Protein

Immobilized Human DSG-2, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 18.2ng/ml determined by ELISA.

SDS-PAGE gel of Human DSG-2/Desmoglein-2 Protein

Human DSG-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.