Human Neuropilin-2 Protein 3545

$300.00 – $1,000.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gln23-Pro859

SKU: 3545parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	NP_003863.2
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.
molecular weight	The protein has a predicted MW of 95.4 kDa. Due to glycosylation, the protein migrates to 110-115 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Neuropilin-2 Protein 3545

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). NRP2 is important for migration, antigen presentation, phagocytosis and cell-cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells.
Protein names Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2)
Protein family Neuropilin family
Mass 104831Da
Function High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.; (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. {ECO:0000269\|PubMed:30057110}.
Subellular location Membrane {ECO:0000269\|PubMed:11112349}; Single-pass type I membrane protein {ECO:0000269\|PubMed:11112349}.; [Isoform s9]: Secreted {ECO:0000269\|PubMed:11112349}.
Structure Heterodimer with NRP1. Binds PLXNB1. {ECO:0000269\|PubMed:17989695}.; (Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A. {ECO:0000269\|PubMed:30057110}.
Domain The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are resp
Target Relevance information above includes information from UniProt accession: O60462
The UniProt Consortium

The purity of Human Neuropilin-2 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human Neuropilin-2 Protein

Human Neuropilin-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.