Mouse Serum Albumin Protein 3378

$180.00 – $600.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Glu25-Ala608

SKU: 3378parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P07724
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
background	Albumins are multifunctional proteins present in the blood serum of animals. They can bind and transport a wide variety of ligands which they accommodate due to their conformational flexibility. Serum albumins are highly conserved both in amino acid sequence and three-dimensional structure. Several mammalian and avian serum albumins (SAs) are also allergens. Sensitization to one of the SAs coupled with the high degree of conservation between SAs may result in cross-reactive antibodies in allergic individuals.
molecular weight	The protein has a predicted MW of 70.19 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1 EU per ug by the LAL method.

Mouse Serum Albumin Protein 3378

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Albumins are multifunctional proteins present in the blood serum of animals. They can bind and transport a wide variety of ligands which they accommodate due to their conformational flexibility. Serum albumins are highly conserved both in amino acid sequence and three-dimensional structure. Several mammalian and avian serum albumins (SAs) are also allergens. Sensitization to one of the SAs coupled with the high degree of conservation between SAs may result in cross-reactive antibodies in allergic individuals.
Protein names Albumin
Gene names Alb,Alb Alb-1 Alb1
Protein family ALB/AFP/VDB family
Mass 10090Da
Function Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity).
Catalytic activity BINDING 27; /ligand="Cu cation"; /ligand_id="ChEBI:CHEBI:23378"; /evidence="ECO:0000250\|UniProtKB:P02770"; BINDING 30; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="1"; /evidence="ECO:0000250\|UniProtKB:P02769"; BINDING 37; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="2"; /evidence="ECO:0000250\|UniProtKB:P02769"; BINDING 91; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250\|UniProtKB:P02768"; BINDING 268; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="1"; /evidence="ECO:0000250\|UniProtKB:P02769"; BINDING 271; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250\|UniProtKB:P02768"; BINDING 273; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="1"; /evidence="ECO:0000250\|UniProtKB:P02769"; BINDING 273; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /evidence="ECO:0000250\|UniProtKB:P02768"; BINDING 276; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="1"; /evidence="ECO:0000250\|UniProtKB:P02769"; BINDING 279; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; /ligand_label="2"; /evidence="ECO:0000250\|UniProtKB:P02769"
Subellular location Secreted.
Tissues Plasma. Expressed in the granular cells within the cerebellum (PubMed:31112734).
Structure Part of a complex composed of complement component C3, CLCA1/CLCA3, A2ML1/OH and ALB/serum albumin (PubMed:30899053). Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (PubMed:31112734). In plasma, occurs in a covalently-linked complex with chromophore-bound alpha-1-microglobulin; this interaction does not prevent fatty acid binding to ALB.
Post-translational modification Phosphorylated by FAM20C in the extracellular medium.
Target Relevance information above includes information from UniProt accession: P07724
The UniProt Consortium

Mouse Serum Albumin, His Tag immobilized on CM5 Chip can bind Mouse FcRn, His Tag with an affinity constant of 54.53 nM as determined in SPR assay (Biacore T200).

The purity of Mouse Serum Albumin is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse Serum Albumin Protein

Mouse Serum Albumin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.