| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| accession | F6QSK2(ITGAV)&F7F3K9(ITGB8) |
| express system | HEK293 |
| product tag | C-His |
| purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| background | Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation. |
| molecular weight | The protein has a predicted MW of 112.1 kDa (ITGAV) and 75.3 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-140 kDa based on Tris-Bis PAGE result. |
| available size | 100 µg, 500 µg |
| endotoxin | Less than 1EU per μg by the LAL method. |
Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein 5105
$375.00 – $1,250.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Phe31-Pro993(ITGAV) acidic tail & Glu43-Ser681(ITGB8) basic tail
Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein 5105
| protein |
|---|
| Size and concentration 100, 500µg and lyophilized |
| Form Lyophilized |
| Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Storage buffer Shipped at ambient temperature. |
| Purity > 95% as determined by Tris-Bis PAGE |
| target relevance |
|---|
| Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation. |
| Protein names Integrin subunit alpha V |
| Gene names ITGAV,ITGAV |
| Protein family Integrin alpha chain family |
| Mass 116488Da |
| Subellular location Membrane ; Single-pass type I membrane protein . |
| Target Relevance information above includes information from UniProt accession: F6QSK2 |
| The UniProt Consortium |
 |
| Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 11.6ng/ml determined by ELISA. |
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| The purity of Rhesus macaque ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC. |
 |
| Rhesus macaque ITGAV&ITGB8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
| pmid | title | authors | citation |
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| We haven't added any publications to our database yet. | |||
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