Human CDH3/Cadherin 3 Protein 3342

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Asp108-Gly654

SKU: 3342parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P22223
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
molecular weight	The protein has a predicted MW of 64.32 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CDH3/Cadherin 3 Protein 3342

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration.
Protein names Cadherin-3 (Placental cadherin) (P-cadherin)
Gene names CDH3,CDH3 CDHP
Mass 91418Da
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subellular location Cell membrane; Single-pass type I membrane protein.
Tissues Expressed in some normal epithelial tissues and in some carcinoma cell lines.
Structure Interacts with CDCP1 and CTNNB1.
Domain TOPO_DOM 1
Target Relevance information above includes information from UniProt accession: P22223
The UniProt Consortium

Data

ELISA with Human CDH3/Cadherin 3 Protein

Immobilized Anti-CDH3 Antibody, hFc Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human CDH3, His Tag with the EC50 of 2.4µg/ml determined by ELISA.

The purity of Human CDH3 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human CDH3/Cadherin 3 Protein

Human CDH3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.