Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein 3261

$375.00 – $1,250.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail

available size

Clear

SKU: 3261parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q62469(ITGA2)&P09055(ITGB1)
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.
molecular weight	The protein has a predicted MW of 126.60 kDa(ITGA2)&82.80 kDa(ITGB1). Due to glycosylation, the protein migrates to 128-138 kDa(ITGA2)&105-115 kDa(ITGB1) based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein 3261

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.
Protein names Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)
Gene names Itga2,Itga2
Protein family Integrin alpha chain family
Mass 128955Da
Function Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.
Subellular location Membrane; Single-pass type I membrane protein.
Structure Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.
Domain The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo pro
Target Relevance information above includes information from UniProt accession: Q62469
The UniProt Consortium

Data

HPLC of Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein

The purity of Mouse ITGA2&ITGB1 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer

Mouse ITGA2&ITGB1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.