Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q80YX1 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. |
molecular weight | The protein has a predicted MW of 65.65 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse Tenascin Protein 5094
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Gly23-Ser621
Mouse Tenascin Protein 5094
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. |
Protein names Tenascin (TN) (Hexabrachion) (Tenascin-C) (TN-C) |
Gene names Tnc,Tnc Hxb |
Protein family Tenascin family |
Mass 10090Da |
Function Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). |
Subellular location Secreted, extracellular space, extracellular matrix . |
Tissues Expressed in the corneal limbus, the periosteum and the rib molecular layer of the cerebellum, the matrix of kidney tubules, blood vessels, stomach and intestine (at protein level).; [Isoform 2]: Weakly expressed in the brain.; [Isoform 5]: Highly expressed in the thymus and moderately expressed in the brain. |
Structure Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4 (By similarity). Interacts (via the 3rd fibronectin type-III domain) with integrin ITGA9:ITGB1 (PubMed:22654117). |
Post-translational modification N-glycosylated. |
Target Relevance information above includes information from UniProt accession: Q80YX1 |
The UniProt Consortium |
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The purity of Mouse Tenascin is greater than 95% as determined by SEC-HPLC. |
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Mouse Tenascin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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