Canine keratin, type I cytoskeletal 19 (310-399) Protein 3100

$240.00 – $800.00

Summary

Expression: E.coli
Pure: Yes (HPLC)
Amino Acid Range: Gln310-Leu399

available size

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SKU: 3100parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	NP_001240671
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker.
molecular weight	The protein has a predicted MW of 21.84 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Canine keratin, type I cytoskeletal 19 (310-399) Protein 3100

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Keratin 19 (K19) belongs to the keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker.
Protein names Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Protein family Intermediate filament family
Mass 44106Da
Function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {ECO:0000269\|PubMed:16000376}.
Tissues Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. {ECO:0000269\|PubMed:16000376, ECO:0000269\|PubMed:2468493, ECO:0000269\|PubMed:2469734}.
Structure Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein. {ECO:0000269\|PubMed:10809736, ECO:0000269\|PubMed:16000376}.; (Microbial infection) Interacts with hepatitis C virus/HCV core protein. {ECO:0000269\|PubMed:15846844}.
Domain This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Target Relevance information above includes information from UniProt accession: P08727
The UniProt Consortium

Data

HPLC of Canine keratin, type I cytoskeletal 19 (310-399) Protein

The purity of Canine keratin, type I cytoskeletal 19 (310-399) is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Canine keratin, type I cytoskeletal 19 (310-399) Protei

Canine keratin, type I cytoskeletal 19 (310-399) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.