Mouse FOLR1 Protein 3037

$285.00 – $950.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Thr25-Ser232

SKU: 3037parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P35846
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 – 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
molecular weight	The protein has a predicted MW of 25.36 kDa. Due to glycosylation, the protein migrates to 33-43 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse FOLR1 Protein 3037

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Protein names Folate receptor alpha (FR-alpha) (Folate receptor 1) (Folate-binding protein 1)
Gene names Folr1,Folr1 Fbp1 Folbp1
Protein family Folate receptor family
Mass 10090Da
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271).
Catalytic activity BINDING 101; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P15328"; BINDING 105; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P15328"; BINDING 122..126; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P15328"; BINDING 155..160; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P15328"; BINDING 194; /ligand="folate"; /ligand_id="ChEBI:CHEBI:62501"; /evidence="ECO:0000250\|UniProtKB:P15328"
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor. Apical cell membrane ; Lipid-anchor, GPI-anchor. Basolateral cell membrane ; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.
Tissues Detected in kidney proximal tubules (at protein level).
Post-translational modification The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Target Relevance information above includes information from UniProt accession: P35846
The UniProt Consortium

The purity of Mouse FOLR1 is greater than 95% as determined by SEC-HPLC.

Mouse FOLR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.