no metadatahttps://benchmarkantibodies.com/product/human-cdh17-cadherin-17-domain-12-protein-9072/
Skip to content

Human CDH17/Cadherin 17 Domain 1&2 Protein 9072

$390.00$1,300.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Pro30-Pro244
SKU: 9072parent Categories: , Tag:
Weight 1 lbs
Dimensions 9 × 5 × 2 in
accession

Q12864

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE

background

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.

molecular weight

The protein has a predicted MW of 25.15 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human CDH17/Cadherin 17 Domain 1&2 Protein 9072

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Protein names
Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin)
Gene names
CDH17,CDH17
Mass
9606Da
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
Domain
Th
Target Relevance information above includes information from UniProt accession: Q12864
The UniProt Consortium

Data

benchmark-antibodies_anti-daxx_ct_antibody_8072_1.jpg
Western blot analysis of Daxx in 293 total cell lysate with Dax antibody at 1 mg/mL.
benchmark-antibodies_anti-daxx_ct_antibody_8072_2.jpg
Immunocytochemistry of DAXX in HeLa cells with DAXX antibody at 10 µg/mL.
benchmark-antibodies_anti-daxx_ct_antibody_8072_3.gif
Immunofluorescence of Daxx in Hela cells with Daxx antibody at 20 µg/mL. Green: Daxx Antibody (8072)
Blue: DAPI staining
ELISA with Human CDH17/Cadherin 17 Domain 1&2 Protein
Immobilized Human CDH17 Domain 1&2, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA.
SDS-PAGE gel of Human CDH17/Cadherin 17 Domain 1&2 Protein
Human CDH17 Domain 1&2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Publications

pmid title authors citation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product

Documents

#
Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information.