Cynomolgus Transthyretin/Prealbumin Protein 2825

$315.00 – $1,050.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gly21-Glu147

available size

Clear

SKU: 2825parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q8HXW1
express system	HEK293
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
molecular weight	The protein has a predicted MW of 14.80 kDa. Due to glycosylation, the protein migrates to 16-20 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus Transthyretin/Prealbumin Protein 2825

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in the nervous system. TTR aggregates are responsible for many amyloidosis such as familial amyloidotic polyneuropathy and cardiomyopathy. Normal TTR can also aggregate and deposit in the heart of old people and in preeclampsia placental tissue.
Protein names Transthyretin (Prealbumin)
Gene names TTR,TTR QccE-10711 QccE-14396
Protein family Transthyretin family
Mass 9541Da
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity).
Catalytic activity BINDING 35; /ligand="L-thyroxine"; /ligand_id="ChEBI:CHEBI:58448"; /evidence="ECO:0000250\|UniProtKB:P02766"; BINDING 74; /ligand="L-thyroxine"; /ligand_id="ChEBI:CHEBI:58448"; /evidence="ECO:0000250\|UniProtKB:P02766"; BINDING 137; /ligand="L-thyroxine"; /ligand_id="ChEBI:CHEBI:58448"; /evidence="ECO:0000250\|UniProtKB:P02766"
Subellular location Secreted .
Structure Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).
Post-translational modification Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
Target Relevance information above includes information from UniProt accession: Q8HXW1
The UniProt Consortium

Data

HPLC of Cynomolgus Transthyretin/Prealbumin Protein

The purity of Cynomolgus Transthyretin is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus Transthyretin/Prealbumin Protein

Cynomolgus Transthyretin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.