Human Tubby Protein 2731

$345.00 – $1,150.00

Summary

Expression: E.coli
Pure: Yes (SDS-PAGE)
Amino Acid Range: Met1-Glu506

SKU: 2731parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P50607
express system	E.coli
product tag	N-His
purity	> 95% as determined by Tris-Bis PAGE
background	Tubby is the founding member of the tubby-like family of proteins. Tubby-like proteins (TLPs) possess a highly conserved closed β barrel tubby domain at C-terminal and N-terminal F-box.Tubby plays a critical role in trafficking select GPCRs to the cilia.
molecular weight	The protein has a predicted MW of 56.74 kDa same as Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Tubby Protein 2731

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Tubby is the founding member of the tubby-like family of proteins. Tubby-like proteins (TLPs) possess a highly conserved closed β barrel tubby domain at C-terminal and N-terminal F-box.Tubby plays a critical role in trafficking select GPCRs to the cilia.
Protein names Tubby protein homolog
Gene names TUB,TUB
Protein family TUB family
Mass 9606Da
Function Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
Catalytic activity #N/A
Subellular location Cytoplasm. Nucleus. Secreted. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
Structure Interacts with GNAQ. Interacts with TULP1.
Target Relevance information above includes information from UniProt accession: P50607
The UniProt Consortium

Data

Human Tubby on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.