Human ULBP-6 Protein 2663

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Arg26-Gly218

SKU: 2663parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q5VY80
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	ULBP6/RAET1L (UL16-binding protein, also known as retinoic acid early transcript), is expressed as a full-lengthtranscript in cells and encodes a protein that is a ligand for bothNKG2D and the UL16 protein of HCMV.
molecular weight	The protein has a predicted MW of 48.61 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human ULBP-6 Protein 2663

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
ULBP6/RAET1L (UL16-binding protein, also known as retinoic acid early transcript), is expressed as a full-lengthtranscript in cells and encodes a protein that is a ligand for bothNKG2D and the UL16 protein of HCMV.
Protein names UL16-binding protein 6 (Retinoic acid early transcript 1L protein)
Gene names RAET1L,RAET1L ULBP6
Protein family MHC class I family
Mass 9606Da
Function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=In CMV-infected fibroblasts, detected intracellularly.
Tissues Widely expressed (PubMed:11827464). Expressed in trachea (PubMed:19658097). Constitutively expressed in peripheral blood mononuclear cells, including B-cells and natural killer cells, as well as CD4+ and CD8+ T-cells and monocytes. Tends to be up-regulated in various lymphoid malignancies, including chronic lymphocytic leukemia (PubMed:28559451).
Structure Interacts with KLRK1/NKG2D.; (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes relocalization from the cell surface to the cytoplasm and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
Target Relevance information above includes information from UniProt accession: Q5VY80
The UniProt Consortium

Data

Immobilized Human NKG2D, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human ULBP-6, hFc Tag with the EC50 of 2.2ng/ml determined by ELISA.

The purity of Human ULBP-6 is greater than 95% as determined by SEC-HPLC.

Human ULBP-6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.