Cynomolgus NKp46/NCR1/CD335 Protein 2659

$315.00 – $1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Pro22-Asn254

available size

Clear

SKU: 2659parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q95JB9
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
molecular weight	The protein has a predicted MW of 53.1 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus NKp46/NCR1/CD335 Protein 2659

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
Protein names Natural cytotoxicity triggering receptor 1 (Natural killer cell p46-related protein) (NK-p46) (NKp46) (CD antigen CD335)
Gene names NCR1,NCR1
Protein family Natural cytotoxicity receptor (NCR) family
Mass 9541Da
Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
Subellular location Cell membrane ; Single-pass type I membrane protein .
Tissues Expressed in NK cells.
Structure Interacts with CD3Z and FCER1G.
Target Relevance information above includes information from UniProt accession: Q95JB9
The UniProt Consortium

Data

ELISA with Cynomolgus NKp46/NCR1/CD335 Protein

Immobilized Cynomolgus NKp46, hFc Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Anti-Nkp46 Antibody, hFc Tag with the EC50 of 32.5ng/ml determined by ELISA.

HPLC of Cynomolgus NKp46/NCR1/CD335 Protein

The purity of Cynomolgus NKp46 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus NKp46/NCR1/CD335 Protein

Cynomolgus NKp46 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.