Cynomolgus CCL24 Protein 2570

$1,050.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: His19-His119

SKU: 2570parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_005549400
express system	HEK293
product tag	N-His
purity	> 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver.
molecular weight	The protein has a predicted MW of 12.36 kDa. Due to glycosylation, the protein migrates to 23-38 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Cynomolgus CCL24 Protein 2570

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver.
Protein names C-C motif chemokine 24 (CK-beta-6) (Eosinophil chemotactic protein 2) (Eotaxin-2) (Myeloid progenitor inhibitory factor 2) (MPIF-2) (Small-inducible cytokine A24)
Gene names CCL24,CCL24 MPIF2 SCYA24
Protein family Intercrine beta (chemokine CC) family
Mass 9606Da
Function Chemotactic for resting T-lymphocytes, and eosinophils (PubMed:9104803, PubMed:9365122). Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes (PubMed:9104803, PubMed:9365122). Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line (PubMed:9104803, PubMed:9365122). Binds to CCR3 (PubMed:9104803, PubMed:9365122).
Subellular location Secreted .
Tissues Activated monocytes and activated T lymphocytes.
Post-translational modification N-glycosylated.
Target Relevance information above includes information from UniProt accession: O00175
The UniProt Consortium

Data

Immobilized Cynomolgus CCL24, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Anti-CCL24 Antibody, hFc Tag with the EC50 of 18.7ng/ml determined by ELISA.

The purity of Cynomolgus CCL24 is greater than 90% as determined by SEC-HPLC.

SDS-PAGE gel of Cynomolgus CCL24 Protein

Cynomolgus CCL24 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.