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Oct4
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
| target | type | reactivity | applications | ||||
|---|---|---|---|---|---|---|---|
| 6299 | Oct4 | rabbit monoclonal | human | IHC | |||
| 6300 | Oct4 | mouse monoclonal | human | IHC | |||
IHC with antibody [6300] : Human seminoma stained with anti-OCT-4 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of seminoma cells.
IHC with antibody [6297] : Formalin-fixed, paraffin-embedded human lymph node stained with anti-OCT2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular B cells
IHC with antibody [6298] : Human lymph node stained with anti-OCT-2 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of follicular center B cells.
