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MLH-1

MLH-1: MLH-1 is a key component of the mismatch repair (MMR) system, and its loss of expression is indicative of microsatellite instability (MSI). This is particularly relevant in colorectal cancers associated with Lynch syndrome, providing important diagnostic and prognostic information.



Human colon adenocarcinoma with Lynch syndrome stained with anti-MLH-1 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background non tumor cells are positive.
IHC with antibody [6257] : Human colon adenocarcinoma with Lynch syndrome stained with anti-MLH-1 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background non tumor cells are positive.
Human colon adenocarcinoma with Lynch syndrome stained with anti-MLH-1 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background non tumor cells are positive.
IHC with antibody [6258] : Human colon adenocarcinoma with Lynch syndrome stained with anti-MLH-1 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background non tumor cells are positive.
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