Calreticulin antibodies

Calreticulin is a multifunctional calcium-binding chaperone protein primarily located in the endoplasmic reticulum (ER), where it plays a critical role in protein folding, quality control, and calcium homeostasis. It assists in the proper folding of newly synthesized glycoproteins and ensures that only correctly folded proteins exit the ER. Calreticulin is also involved in immune response modulation and cell adhesion processes, making it relevant in various physiological and pathological contexts, including cancer, autoimmune diseases, and cardiac development.In Western blotting (WB), calreticulin is commonly used as a marker for ER stress and protein-folding capacity. The calreticulin antibodies offered on your website are also suitable for immunofluorescence (IF) and immunohistochemistry (IHC), allowing researchers to visualize its expression and localization in the ER and other compartments within cells. This helps investigate ER stress, apoptosis, and immune-related pathways, particularly in cancer and inflammatory diseases, where calreticulin exposure on the cell surface can trigger immune recognition.Given its essential role in ER function, protein folding, and calcium regulation, calreticulin is a valuable marker in studies focusing on cellular stress, immune modulation, and protein quality control. It is especially important in research on cancer, autoimmunity, and cardiovascular diseases, where its expression and function are often dysregulated.