Sample type Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Storage Store at 2-8°C.
target relevance
anti-Tirzepatide antibody an autoantibody against anti-Tirzepatide antibody genereted in a administered subject
Tirzepatide Tirzepatide biologic drug binds Homo sapiens GLP1R,Homo sapiens GIPR
Homo sapiens GLP1R Glucagon-like peptide 1 receptor
Protein names Glucagon-like peptide 1 receptor
Gene names GLP1R
Protein family Belongs to the G-protein coupled receptor 2 family
Function G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)
Subcellular location Cell membrane
Structure May form homodimers and heterodimers with GIPR
Post-translational modification N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER
Homo sapiens GIPR Gastric inhibitory polypeptide receptor
Protein names Gastric inhibitory polypeptide receptor
Alternative names Glucose-dependent insulinotropic polypeptide receptor
Gene names GIPR
Protein family Belongs to the G protein-coupled receptor 2 family
Function This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase
Subcellular location Cell membrane
Structure May form homodimers and heterodimers with GLP1R
Post-translational modification N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER
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Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
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