Sample type Serum, Plasma, Cell Culture Supernatant, Other liquid samples
Components
Break apart microtiter test strips each coated single wells
8 x 12 (96 Total)
Lyophilized Standard
2 x vial
Biotin-labeled Antibody(Concentrated, 100X)
120 uL
HRP-Streptavidin Conjugate(Concentrated, 100X)
120 uL
Washing solution concentrate (25X)
30 mL
Sample Dilution buffer
20 mL
Antibody Dilution buffer
10 mL
Streptavidin Dilution buffer
10 mL
Stopping solution
10 mL
TMB Substrate (ready-to-use)
10 mL
Plate seals
3
Storage Store at 2-8°C.
target relevance
anti-Timolumab antibody Anti-drug antibodies (ADAs) generated in subjects following administration of Timolumab.
Timolumab Timolumab biologic drug binds Homo sapiens AOC3 Amine oxidase [copper-containing] 3
Homo sapiens AOC3 Amine oxidase [copper-containing] 3
Protein names Amine oxidase [copper-containing] 3
Alternative names Amine oxidase copper-containing 3, Copper amine oxidase, HPAO, Semicarbazide-sensitive amine oxidase, Vascular adhesion protein 1
Gene names AOC3
Protein family Belongs to the copper/topaquinone oxidase family
Function Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, PubMed:9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed:9254657, PubMed:9653080)
Structure Homodimer; disulfide-linked (PubMed:16046623). Can heterodimerize with isoform 2 leading to reduced surface expression (PubMed:23349812). Probably forms heterodimers with AOC2 (PubMed:19588076)
Post-translational modification Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue N- and O-glycosylated
Keywords 3D-structure, Alternative splicing, Calcium, Cell adhesion, Cell membrane, Copper, Direct protein sequencing, Disulfide bond, Glycoprotein, Membrane, Metal-binding, Oxidoreductase, Proteomics identification, Reference proteome, Signal-anchor, TPQ, Transmembrane, Transmembrane helix
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
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