Sample type Serum, Plasma, Cell Culture Supernatant, Other liquid samples
Components
Break apart microtiter test strips each coated single wells
8 x 12 (96 Total)
Lyophilized Standard
2 x vial
Biotin-labeled Antibody(Concentrated, 100X)
120 uL
HRP-Streptavidin Conjugate(Concentrated, 100X)
120 uL
Washing solution concentrate (25X)
30 mL
Sample Dilution buffer
20 mL
Antibody Dilution buffer
10 mL
Streptavidin Dilution buffer
10 mL
Stopping solution
10 mL
TMB Substrate (ready-to-use)
10 mL
Plate seals
3
Storage Store at 2-8°C.
target relevance
anti-Diridavumab antibody Anti-drug antibodies (ADAs) generated in subjects following administration of Diridavumab.
Diridavumab Diridavumab biologic drug binds Influenza A virus (strain A/Japan/305/1957 H2N2) HA Hemagglutinin
Influenza A virus (strain A/Japan/305/1957 H2N2) HA Hemagglutinin
Protein names Hemagglutinin
Gene names HA
Protein family Belongs to the influenza viruses hemagglutinin family
Function Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore
Post-translational modification Palmitoylated In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by club cells
Keywords 3D-structure, Clathrin- and caveolin-independent endocytosis of virus by host, Clathrin-mediated endocytosis of virus by host, Disulfide bond, Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Glycoprotein, Hemagglutinin, Host cell membrane, Host membrane, Host-virus interaction, Lipoprotein, Membrane, Palmitate, Signal, Transmembrane, Transmembrane helix, Viral attachment to host cell, Viral envelope protein, Viral penetration into host cytoplasm, Virion, Virus endocytosis by host, Virus entry into host cell
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
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