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MSH-6
MSH-6: MSH-6 is another protein involved in the mismatch repair system. Loss of expression is associated with microsatellite instability and can indicate a predisposition to certain cancers, particularly colorectal cancer, aiding in diagnosis and treatment planning.
target | type | reactivity | applications | ||||
---|---|---|---|---|---|---|---|
6262 | MSH-6 | mouse monoclonal (ZM99) | human | IHC | |||
6263 | MSH-6 | rabbit monoclonal (ZR342) | human | IHC |
IHC with antibody [6262] : Human colon adenocarcinoma with Lynch syndrome stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background cells are positive.
IHC with antibody [6263] : Formalin-fixed, paraffin-embedded human colon carcinoma (Lynch) stained with anti-MSH-6 antibody using peroxidase-conjugate and DAB chromogen. Note the absence of nuclear staining of tumor cells whereas normal lymphocytes and stromal cells are positive.