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MSH-2 – benchmark antibodies MSH-2
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MSH-2

MSH-2: MSH-2 is a mismatch repair protein involved in DNA repair and is essential for diagnosing Lynch syndrome and associated tumors. Its loss of expression is indicative of microsatellite instability (MSI) and can guide treatment decisions, particularly in colorectal cancer.



Human colon adenocarcinoma with Lynch syndrome stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background cells are positive.
IHC with antibody [6260] : Human colon adenocarcinoma with Lynch syndrome stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note absence of nuclear staining of tumor cells whereas the background cells are positive.
Formalin-fixed, paraffin-embedded human colon adenocarcinoma stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note the absence nuclear staining of tumor cells and the presence of nuclear staining of normal mucosa
IHC with antibody [6430] : Formalin-fixed, paraffin-embedded human colon adenocarcinoma stained with anti-MSH-2 antibody using peroxidase-conjugate and DAB chromogen. Note the absence nuclear staining of tumor cells and the presence of nuclear staining of normal mucosa
ICC
IHC