Sample type Serum, Plasma, Cell Culture Supernatant, Other liquid samples
Components
Break apart microtiter test strips each coated single wells
8 x 12 (96 Total)
Lyophilized Standard
2 x vial
Biotin-labeled Antibody(Concentrated, 100X)
120 uL
HRP-Streptavidin Conjugate(Concentrated, 100X)
120 uL
Washing solution concentrate (25X)
30 mL
Sample Dilution buffer
20 mL
Antibody Dilution buffer
10 mL
Streptavidin Dilution buffer
10 mL
Stopping solution
10 mL
TMB Substrate (ready-to-use)
10 mL
Plate seals
3
Storage Store at 2-8°C.
target relevance
anti-Erenumab antibody Anti-drug antibodies (ADAs) generated in subjects following administration of Erenumab.
Erenumab Erenumab biologic drug binds Homo sapiens CALCRL Calcitonin gene-related peptide type 1 receptor
Homo sapiens CALCRL Calcitonin gene-related peptide type 1 receptor
Protein names Calcitonin gene-related peptide type 1 receptor
Alternative names Calcitonin receptor-like receptor
Gene names CALCRL
Protein family Belongs to the G-protein coupled receptor 2 family
Function G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685)
Subcellular location Cell membrane
Structure Heterodimer of CALCRL and RAMP1; the receptor complex functions as CGRP receptor (PubMed:20826335, PubMed:33602864). Heterodimer of CALCRL and RAMP2 or CALCRL and RAMP3; the complexes function as adrenomedullin receptor (PubMed:22102369, PubMed:30115739, PubMed:32296767)
Involvement in disease Lymphatic malformation 8 A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Adult patients with lymphedema may suffer from recurrent local infections. Impaired lymphatic drainage in the fetus can develop into hydrops fetalis, a severe condition characterized by excessive fluid accumulation in more than two fetal extra-vascular compartments and body cavities, placental enlargement and edema, pericardial or pleural effusion, or ascites. LMPHM8 is an autosomal recessive form characterized by onset in utero and fetal death due to non-immune hydrops fetalis.
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
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