Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | NP_001121124 |
express system | E.coli |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Mitochondrial Creatine Kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine, and exists in mammals as two isoenzymes encoded by separate genes. In rats and humans, sarcomere-specific MtCK (sMtCK) is expressed only in skeletal and heart muscle, and has 87% nucleotide identity across the 1257 bp coding region. |
molecular weight | The protein has a predicted MW of 44.48 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Rat CKMT2 Protein 2461
$315.00 – $1,050.00
Summary
- Expression: E.coli
- Pure: Yes (HPLC)
- Amino Acid Range: Asp40-Lys419
Rat CKMT2 Protein 2461
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Mitochondrial Creatine Kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine, and exists in mammals as two isoenzymes encoded by separate genes. In rats and humans, sarcomere-specific MtCK (sMtCK) is expressed only in skeletal and heart muscle, and has 87% nucleotide identity across the 1257 bp coding region. |
Protein names Creatine kinase S-type, mitochondrial (EC 2.7.3.2) (Basic-type mitochondrial creatine kinase) (Mib-CK) (Sarcomeric mitochondrial creatine kinase) (S-MtCK) |
Protein family ATP:guanido phosphotransferase family |
Mass 47504Da |
Function Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
Catalytic activity CATALYTIC ACTIVITY: Reaction=ATP + creatine = ADP + H(+) + N-phosphocreatine; Xref=Rhea:RHEA:17157, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092, ChEBI:CHEBI:456216; EC=2.7.3.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10029}; |
Subellular location Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. |
Tissues Sarcomere-specific. Found only in heart and skeletal muscles. |
Structure Exists as an octamer composed of four CKMT2 homodimers. {ECO:0000269|Ref.5}. |
Target Relevance information above includes information from UniProt accession: P17540 |
The UniProt Consortium |
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The purity of Rat CKMT2 is greater than 95% as determined by SEC-HPLC. |
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Rat CKMT2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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